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Xigduo XR (dapagliflozin and metformin HCl extended release) is indicated as substitution therapy for treatment of type 2 diabetes mellitus in adjunct to diet and exercise to improve glycemic control in adults patients already controlled with dapagliflozin and metformin XR given concurrently at the same dose level. (See Pharmacology: Pharmacodynamics: Clinical Trial Information under Actions and Precautions for available data on combination therapy).